Gastric-floating microcapsules provide controlled and sustained release of multiple cardiovascular drugs

Gastric-floating microcapsules provide controlled and sustained release of multiple cardiovascular drugs

Floating polymeric microcapsules that simultaneously entrap multiple drugs were prepared using a solid/water/oil/water emulsion solvent evaporation method, based on harnessing interfacial phenomena and manipulation of the solvent removal process. The fabricated microcapsules exhibited excellent buoy...

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Main Authors: Lee, Wei Li, Wee, Peixin, Nugraha, Chandra, Loo, Say Chye Joachim
Other Authors: School of Materials Science & Engineering
Format: Article
Language:English
Published: 2013
Subjects:
DRNTU::Engineering::Materials::Biomaterials
Online Access:https://hdl.handle.net/10356/79323
http://hdl.handle.net/10220/16451
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Institution: Nanyang Technological University
Language: English
id sg-ntu-dr.10356-79323
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spelling sg-ntu-dr.10356-793232023-07-14T15:49:30Z Gastric-floating microcapsules provide controlled and sustained release of multiple cardiovascular drugs Lee, Wei Li Wee, Peixin Nugraha, Chandra Loo, Say Chye Joachim School of Materials Science & Engineering DRNTU::Engineering::Materials::Biomaterials Floating polymeric microcapsules that simultaneously entrap multiple drugs were prepared using a solid/water/oil/water emulsion solvent evaporation method, based on harnessing interfacial phenomena and manipulation of the solvent removal process. The fabricated microcapsules exhibited excellent buoyancy in simulated gastric fluid and provided controlled and sustained release of multiple drugs for up to 24 h, thus revealing their potential as a rate-controlled oral drug delivery system. ASTAR (Agency for Sci., Tech. and Research, S’pore) Published Version 2013-10-10T09:25:51Z 2019-12-06T13:22:33Z 2013-10-10T09:25:51Z 2019-12-06T13:22:33Z 2013 2013 Journal Article Lee, W. L., Wee, P., Nugraha, C., & Loo, S. C. J. (2013). Gastric-floating microcapsules provide controlled and sustained release of multiple cardiovascular drugs. Journal of Materials Chemistry B, 1(8), 1090-1095. https://hdl.handle.net/10356/79323 http://hdl.handle.net/10220/16451 10.1039/c2tb00495j en Journal of materials chemistry B © 2013 Royal Society of Chemistry. This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic DRNTU::Engineering::Materials::Biomaterials
spellingShingle DRNTU::Engineering::Materials::Biomaterials
Lee, Wei Li
Wee, Peixin
Nugraha, Chandra
Loo, Say Chye Joachim
Gastric-floating microcapsules provide controlled and sustained release of multiple cardiovascular drugs
description Floating polymeric microcapsules that simultaneously entrap multiple drugs were prepared using a solid/water/oil/water emulsion solvent evaporation method, based on harnessing interfacial phenomena and manipulation of the solvent removal process. The fabricated microcapsules exhibited excellent buoyancy in simulated gastric fluid and provided controlled and sustained release of multiple drugs for up to 24 h, thus revealing their potential as a rate-controlled oral drug delivery system.
author2 School of Materials Science & Engineering
author_facet School of Materials Science & Engineering
Lee, Wei Li
Wee, Peixin
Nugraha, Chandra
Loo, Say Chye Joachim
format Article
author Lee, Wei Li
Wee, Peixin
Nugraha, Chandra
Loo, Say Chye Joachim
author_sort Lee, Wei Li
title Gastric-floating microcapsules provide controlled and sustained release of multiple cardiovascular drugs
title_short Gastric-floating microcapsules provide controlled and sustained release of multiple cardiovascular drugs
title_full Gastric-floating microcapsules provide controlled and sustained release of multiple cardiovascular drugs
title_fullStr Gastric-floating microcapsules provide controlled and sustained release of multiple cardiovascular drugs
title_full_unstemmed Gastric-floating microcapsules provide controlled and sustained release of multiple cardiovascular drugs
title_sort gastric-floating microcapsules provide controlled and sustained release of multiple cardiovascular drugs
publishDate 2013
url https://hdl.handle.net/10356/79323
http://hdl.handle.net/10220/16451
_version_ 1772825762041167872

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