USP15 regulates SMURF2 kinetics through C-lobe mediated deubiquitination

USP15 regulates SMURF2 kinetics through C-lobe mediated deubiquitination

Ubiquitin modification of the TGF-β pathway components is emerging as a key mechanism of TGF-β pathway regulation. To limit TGF-β responses, TGF-β signaling is regulated through a negative feedback loop whereby the E3 ligase SMURF2 targets the TGF-β receptor (TβR) complex for ubiquitin-mediated degr...

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Bibliographic Details
Main Authors: Iyengar, Prasanna Vasudevan, Jaynes, Patrick, Rodon, Laura, Lama, Dilraj, Law, Kai Pong, Lim, Yoon Pin, Verma, Chandra, Seoane, Joan, Eichhorn, Pieter Johan Adam
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2015
Online Access:https://hdl.handle.net/10356/79335
http://hdl.handle.net/10220/38827
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Institution: Nanyang Technological University
Language: English

Internet

https://hdl.handle.net/10356/79335
http://hdl.handle.net/10220/38827

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