USP15 regulates SMURF2 kinetics through C-lobe mediated deubiquitination

• Main Authors: Iyengar, Prasanna Vasudevan, Jaynes, Patrick, Rodon, Laura, Lama, Dilraj, Law, Kai Pong, Lim, Yoon Pin, Verma, Chandra, Seoane, Joan, Eichhorn, Pieter Johan Adam
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2015
• Online Access: https://hdl.handle.net/10356/79335; http://hdl.handle.net/10220/38827
• Institution: Nanyang Technological University

Ubiquitin modification of the TGF-β pathway components is emerging as a key mechanism of TGF-β pathway regulation. To limit TGF-β responses, TGF-β signaling is regulated through a negative feedback loop whereby the E3 ligase SMURF2 targets the TGF-β receptor (TβR) complex for ubiquitin-mediated degr...