Targeting the cell stress response of plasmodium falciparum to overcome artemisinin resistance

• Main Authors: Dogovski, Con, Xie, Stanley C., Burgio, Gaetan, Bridgford, Jess, Mok, Sachel, McCaw, James M., Chotivanich, Kesinee, Kenny, Shannon, Gnädig, Nina, Straimer, Judith, Bozdech, Zbynek, Fidock, David A., Simpson, Julie A., Dondorp, Arjen M., Foote, Simon, Klonis, Nectarios, Tilley, Leann
• Other Authors: Schneider, David S.
• Format: Article
• Language: English
• Published: 2015
• Subjects: DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/79395; http://hdl.handle.net/10220/25824
• Institution: Nanyang Technological University

Successful control of falciparum malaria depends greatly on treatment with artemisinin combination therapies. Thus, reports that resistance to artemisinins (ARTs) has emerged, and that the prevalence of this resistance is increasing, are alarming. ART resistance has recently been linked to mutations...