Parasite biomass-related inflammation, endothelial activation, microvascular dysfunction and disease severity in vivax malaria

• Main Authors: Grigg, Matthew J., Parameswaran, Uma, Piera, Kim A., Price, Ric N., Yeo, Tsin W., Anstey, Nicholas M., Barber, Bridget E., William, Timothy
• 其他作者: Stevenson, Mary M.
• 格式: Article
• 語言: English
• 出版: 2015
• 主題: DRNTU::Science::Biological sciences::Zoology::Invertebrates
• 在線閱讀: https://hdl.handle.net/10356/79442; http://hdl.handle.net/10220/25271

Plasmodium vivax can cause severe malaria, however its pathogenesis is poorly understood. In contrast to P. falciparum, circulating vivax parasitemia is low, with minimal apparent sequestration in endothelium-lined microvasculature, and pathogenesis thought unrelated to parasite biomass. However, th...