Parasite biomass-related inflammation, endothelial activation, microvascular dysfunction and disease severity in vivax malaria

• Main Authors: Grigg, Matthew J., Parameswaran, Uma, Piera, Kim A., Price, Ric N., Yeo, Tsin W., Anstey, Nicholas M., Barber, Bridget E., William, Timothy
• Other Authors: Stevenson, Mary M.
• Format: Article
• Language: English
• Published: 2015
• Subjects: DRNTU::Science::Biological sciences::Zoology::Invertebrates
• Online Access: https://hdl.handle.net/10356/79442; http://hdl.handle.net/10220/25271
• Institution: Nanyang Technological University

Plasmodium vivax can cause severe malaria, however its pathogenesis is poorly understood. In contrast to P. falciparum, circulating vivax parasitemia is low, with minimal apparent sequestration in endothelium-lined microvasculature, and pathogenesis thought unrelated to parasite biomass. However, th...