Effects of F’, F-ANA and LNA modification on the stability of DNA G-quadruplex
Quadruplex is formed by G-tetrads (Fig. a) stacking and it forms at Guanine-rich region. G-quadruplex is reported to have anti-cancer and anti-HIV effect [1]. T0 quadruplex (Fig. b) studied in this project is in (4+0) conformation and has very high symmetry [2]. F’, F-ANA and LNA (Fig. d-f) are modi...
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| Format: | Student Research Poster |
| Language: | English |
| Published: |
2013
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| Online Access: | https://hdl.handle.net/10356/79543 http://hdl.handle.net/10220/11316 |
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| Institution: | Nanyang Technological University |
| Language: | English |
| Summary: | Quadruplex is formed by G-tetrads (Fig. a) stacking and it forms at Guanine-rich region. G-quadruplex is reported to have anti-cancer and anti-HIV effect [1]. T0 quadruplex (Fig. b) studied in this project is in (4+0) conformation and has very high symmetry [2]. F’, F-ANA and LNA (Fig. d-f) are modified sugars and they are highly stable in biological condition, easy to synthesize and soluble in water. Thanks to these beneficial properties, F’, F-ANA and LNA are promising candidates for DNA and RNA based drug design [3-5]. In this project, The effects of F’, F-ANA and LNA modifications on thermal stability of G-quadruplex were studied on the platform of T0 G-quadruplex and characterized by UV melting. [1st Award] |
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