Effects of F’, F-ANA and LNA modification on the stability of DNA G-quadruplex
Quadruplex is formed by G-tetrads (Fig. a) stacking and it forms at Guanine-rich region. G-quadruplex is reported to have anti-cancer and anti-HIV effect [1]. T0 quadruplex (Fig. b) studied in this project is in (4+0) conformation and has very high symmetry [2]. F’, F-ANA and LNA (Fig. d-f) are modi...
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sg-ntu-dr.10356-795432020-09-27T20:29:25Z Effects of F’, F-ANA and LNA modification on the stability of DNA G-quadruplex Li, Zhe Phan Anh Tuan School of Physical and Mathematical Sciences Quadruplex is formed by G-tetrads (Fig. a) stacking and it forms at Guanine-rich region. G-quadruplex is reported to have anti-cancer and anti-HIV effect [1]. T0 quadruplex (Fig. b) studied in this project is in (4+0) conformation and has very high symmetry [2]. F’, F-ANA and LNA (Fig. d-f) are modified sugars and they are highly stable in biological condition, easy to synthesize and soluble in water. Thanks to these beneficial properties, F’, F-ANA and LNA are promising candidates for DNA and RNA based drug design [3-5]. In this project, The effects of F’, F-ANA and LNA modifications on thermal stability of G-quadruplex were studied on the platform of T0 G-quadruplex and characterized by UV melting. [1st Award] 2013-07-12T04:43:53Z 2019-12-06T13:27:55Z 2013-07-12T04:43:53Z 2019-12-06T13:27:55Z 2013 2013 Student Research Poster Li, Z. (2013, March). Effects of F’, F-ANA and LNA Modification on the Stability of DNA G-quadruplex. Presented at Discover URECA @ NTU poster exhibition and competition, Nanyang Technological University, Singapore. https://hdl.handle.net/10356/79543 http://hdl.handle.net/10220/11316 en © 2013 The Author(s). application/pdf |
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Quadruplex is formed by G-tetrads (Fig. a) stacking and it forms at Guanine-rich region. G-quadruplex is reported to have anti-cancer and anti-HIV effect [1]. T0 quadruplex (Fig. b) studied in this project is in (4+0) conformation and has very high symmetry [2]. F’, F-ANA and LNA (Fig. d-f) are modified sugars and they are highly stable in biological condition, easy to synthesize and soluble in water. Thanks to these beneficial properties, F’, F-ANA and LNA are promising candidates for DNA and RNA based drug design [3-5]. In this project, The effects of F’, F-ANA and LNA modifications on thermal stability of G-quadruplex were studied on the platform of T0 G-quadruplex and characterized by UV melting. [1st Award] |
| author2 |
Phan Anh Tuan |
| author_facet |
Phan Anh Tuan Li, Zhe |
| format |
Student Research Poster |
| author |
Li, Zhe |
| spellingShingle |
Li, Zhe Effects of F’, F-ANA and LNA modification on the stability of DNA G-quadruplex |
| author_sort |
Li, Zhe |
| title |
Effects of F’, F-ANA and LNA modification on the stability of DNA G-quadruplex |
| title_short |
Effects of F’, F-ANA and LNA modification on the stability of DNA G-quadruplex |
| title_full |
Effects of F’, F-ANA and LNA modification on the stability of DNA G-quadruplex |
| title_fullStr |
Effects of F’, F-ANA and LNA modification on the stability of DNA G-quadruplex |
| title_full_unstemmed |
Effects of F’, F-ANA and LNA modification on the stability of DNA G-quadruplex |
| title_sort |
effects of f’, f-ana and lna modification on the stability of dna g-quadruplex |
| publishDate |
2013 |
| url |
https://hdl.handle.net/10356/79543 http://hdl.handle.net/10220/11316 |
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1681058234099564544 |