In vitro analyses of the anti-fibrotic effect of SPARC silencing in human Tenon’s fibroblasts : comparisons with mitomycin C

• Main Authors: Seet, Li-Fong, Su, Roseline, Toh, Li Zhen, Wong, Tina T.
• Other Authors: School of Materials Science & Engineering
• Format: Article
• Language: English
• Published: 2013
• Online Access: https://hdl.handle.net/10356/79547; http://hdl.handle.net/10220/17837
• Institution: Nanyang Technological University

Failure of glaucoma filtration surgery (GFS) is commonly attributed to scarring at the surgical site. The human Tenon’s fibroblasts (HTFs) are considered the major cell type contributing to the fibrotic response. We previously showed that SPARC (secreted protein, acidic, rich in cysteine) knockout m...