Monocyte cell membrane-derived nanoghosts for targeted cancer therapy

Monocyte cell membrane-derived nanoghosts for targeted cancer therapy

Core-shell type ‘nanoghosts’ were synthesized with a drug-loaded biodegradable PLGA core and a monocyte cell membrane-derived shell. The nanoghosts were monodisperse with an average size <200 nm, and showed good serum stability for 120 h dox0rubicin loaded nanoghosts showed greater cellular uptak...

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Bibliographic Details
Main Authors: Krishnamurthy, Sangeetha, Gnanasammandhan, M. K., Xie, Chen, Huang, K., Cui, M. Y., Chan, J. M.
Other Authors: School of Chemical and Biomedical Engineering
Format: Article
Language:English
Published: 2016
Subjects:
Serum stability
Mono-disperse
Online Access:https://hdl.handle.net/10356/80507
http://hdl.handle.net/10220/40528
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Institution: Nanyang Technological University
Language: English
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Summary:Core-shell type ‘nanoghosts’ were synthesized with a drug-loaded biodegradable PLGA core and a monocyte cell membrane-derived shell. The nanoghosts were monodisperse with an average size <200 nm, and showed good serum stability for 120 h dox0rubicin loaded nanoghosts showed greater cellular uptake and cytotoxicity compared to non-coated nanoparticle controls in metastatic MCF-7 breast cancer cell lines.

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