Fragment Screening of Human Aquaporin 1

• Main Authors: To, Janet, Torres, Jaume
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2016
• Subjects: Human aquaporin 1; Fragment based drug discovery; Surface plasmon resonance; Thermal shift; Membrane protein
• Online Access: https://hdl.handle.net/10356/80531; http://hdl.handle.net/10220/40530
• Institution: Nanyang Technological University

Aquaporins (AQPs) are membrane proteins that enable water transport across cellular plasma membranes in response to osmotic gradients. Phenotypic analyses have revealed important physiological roles for AQPs, and the potential for AQP water channel modulators in various disease states has been propo...