Multi-drug-loaded Microcapsules with Controlled Release for Management of Parkinson's Disease
Parkinson's disease (PD) is a progressive disease of the nervous system, and is currently managed through commercial tablets that do not sufficient enable controlled, sustained release capabilities. It is hypothesized that a drug delivery system that provides controlled and sustained release of...
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sg-ntu-dr.10356-807422020-09-21T11:34:26Z Multi-drug-loaded Microcapsules with Controlled Release for Management of Parkinson's Disease Baek, Jong-Suep Choo, Chee Chong Qian, Cheng Tan, Nguan Soon Shen, Zexiang Loo, Say Chye Joachim School of Materials Science & Engineering School of Biological Sciences School of Physical and Mathematical Sciences Singapore Centre for Environmental Life Sciences Engineering Parkinson's disease controlled release spray-coating floating drug delivery system Parkinson's disease (PD) is a progressive disease of the nervous system, and is currently managed through commercial tablets that do not sufficient enable controlled, sustained release capabilities. It is hypothesized that a drug delivery system that provides controlled and sustained release of PD drugs would afford better management of PD. Hollow microcapsules composed of poly-L-lactide (PLLA) and poly (caprolactone) (PCL) were prepared through a modified double-emulsion technique. They were loaded with three PD drugs, i.e. levodopa (LD), carbidopa (CD) and entacapone (ENT), at a ratio of 4:1:8, similar to commercial PD tablets. LD and CD were localized in both the hollow cavity and PLLA/PCL shell, while ENT was localized in the PLLA/PCL shell. Release kinetics of hydrophobic ENT was observed to be relatively slow as compared to the other hydrophilic drugs. It was further hypothesized that encapsulating ENT into PCL as a surface coating onto these microcapsules can aid in accelerating its release. Now, these spray-coated hollow microcapsules exhibited similar release kinetics, according to Higuchi’s rate, for all three drugs. The results suggest that multiple drug encapsulation of LD, CD and ENT in gastric floating microcapsules could be further developed for in vivo evaluation for the management of PD. ASTAR (Agency for Sci., Tech. and Research, S’pore) NMRC (Natl Medical Research Council, S’pore) MOH (Min. of Health, S’pore) Accepted version 2016-06-22T08:13:27Z 2019-12-06T13:57:58Z 2016-06-22T08:13:27Z 2019-12-06T13:57:58Z 2016 Journal Article Baek, J.-S., Choo, C. C., Qian, C., Tan, N. S., Shen, Z., & Loo, S. C. J. (2016). Multi-drug-loaded Microcapsules with Controlled Release for Management of Parkinson's Disease. Small, 12(27), 3712-3722 1613-6810 https://hdl.handle.net/10356/80742 http://hdl.handle.net/10220/40745 10.1002/smll.201600067 194057 en Small © 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. This is the author created version of a work that has been peer reviewed and accepted for publication by Small, Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1002/smll.201600067]. 47 p. application/pdf |
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Parkinson's disease controlled release spray-coating floating drug delivery system |
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Parkinson's disease controlled release spray-coating floating drug delivery system Baek, Jong-Suep Choo, Chee Chong Qian, Cheng Tan, Nguan Soon Shen, Zexiang Loo, Say Chye Joachim Multi-drug-loaded Microcapsules with Controlled Release for Management of Parkinson's Disease |
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Parkinson's disease (PD) is a progressive disease of the nervous system, and is currently managed through commercial tablets that do not sufficient enable controlled, sustained release capabilities. It is hypothesized that a drug delivery system that provides controlled and sustained release of PD drugs would afford better management of PD. Hollow microcapsules composed of poly-L-lactide (PLLA) and poly (caprolactone) (PCL) were prepared through a modified double-emulsion technique. They were loaded with three PD drugs, i.e. levodopa (LD), carbidopa (CD) and entacapone (ENT), at a ratio of 4:1:8, similar to commercial PD tablets. LD and CD were localized in both the hollow cavity and PLLA/PCL shell, while ENT was localized in the PLLA/PCL shell. Release kinetics of hydrophobic ENT was observed to be relatively slow as compared to the other hydrophilic drugs. It was further hypothesized that encapsulating ENT into PCL as a surface coating onto these microcapsules can aid in accelerating its release. Now, these spray-coated hollow microcapsules exhibited similar release kinetics, according to Higuchi’s rate, for all three drugs. The results suggest that multiple drug encapsulation of LD, CD and ENT in gastric floating microcapsules could be further developed for in vivo evaluation for the management of PD. |
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School of Materials Science & Engineering |
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School of Materials Science & Engineering Baek, Jong-Suep Choo, Chee Chong Qian, Cheng Tan, Nguan Soon Shen, Zexiang Loo, Say Chye Joachim |
format |
Article |
author |
Baek, Jong-Suep Choo, Chee Chong Qian, Cheng Tan, Nguan Soon Shen, Zexiang Loo, Say Chye Joachim |
author_sort |
Baek, Jong-Suep |
title |
Multi-drug-loaded Microcapsules with Controlled Release for Management of Parkinson's Disease |
title_short |
Multi-drug-loaded Microcapsules with Controlled Release for Management of Parkinson's Disease |
title_full |
Multi-drug-loaded Microcapsules with Controlled Release for Management of Parkinson's Disease |
title_fullStr |
Multi-drug-loaded Microcapsules with Controlled Release for Management of Parkinson's Disease |
title_full_unstemmed |
Multi-drug-loaded Microcapsules with Controlled Release for Management of Parkinson's Disease |
title_sort |
multi-drug-loaded microcapsules with controlled release for management of parkinson's disease |
publishDate |
2016 |
url |
https://hdl.handle.net/10356/80742 http://hdl.handle.net/10220/40745 |
_version_ |
1681058199477682176 |