Identification of a novel sequence type of Escherichia coli as the causative agent of pyelonephritis and bloodstream infection

• Main Authors: Mac Aogáin, Micheál, Miajlovic, Helen, Moloney, Geraldine, Chotirmall, Sanjay Haresh, Rogers, Thomas R., Smith, Stephen G. J.
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2017
• Subjects: Escherichia coli ST-458; Bacteraemia
• Online Access: https://hdl.handle.net/10356/80781; http://hdl.handle.net/10220/42230
• Institution: Nanyang Technological University

Introduction: Globally, extra-intestinal pathogenic Escherichia coli are one of the predominant causative agents of bacteraemia. Case presentation: This case report outlines a presentation of community-acquired pyelonephritis and secondary bloodstream infection in an 81-year-old man. Laboratory investigations revealed that the causative isolate was a multi-drug-resistant E. coli of a novel multi-locus sequence type. This sequence type (ST) was designated ST-458 and was most closely related to the globally prevalent ST-131 lineage. Conclusion: This is the first report of a novel E. coli ST, ST-458, which caused pyelonephritis and bacteraemia.