Emerging functions of alternative splicing coupled with nonsense-mediated decay

• Main Authors: Hamid, Fursham M., Makeyev, Eugene V.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2015
• Subjects: AS-NMD; Development; Post-transcriptional regulation of gene expression; Physiological response; RNA metabolism
• Online Access: https://hdl.handle.net/10356/80870; http://hdl.handle.net/10220/38868
• Institution: Nanyang Technological University

Higher eukaryotes rely on AS (alternative splicing) of pre-mRNAs (mRNA precursors) to generate more than one protein product from a single gene and to regulate mRNA stability and translational activity. An important example of the latter function involves an interplay between AS and NMD (nonsense-me...