A mechanism underlying position-specific regulation of alternative splicing

• Main Authors: Hamid, Fursham M., Makeyev, Eugene V.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2018
• Subjects: Amino Acid Sequence; Alternative RNA Splicing
• Online Access: https://hdl.handle.net/10356/88632; http://hdl.handle.net/10220/44671
• Institution: Nanyang Technological University

Many RNA-binding proteins including a master regulator of splicing in developing brain and muscle, polypyrimidine tract-binding protein 1 (PTBP1), can either activate or repress alternative exons depending on the pre-mRNA recruitment position. When bound upstream or within regulated exons PTBP1 tend...