Emerging functions of alternative splicing coupled with nonsense-mediated decay

Emerging functions of alternative splicing coupled with nonsense-mediated decay

Higher eukaryotes rely on AS (alternative splicing) of pre-mRNAs (mRNA precursors) to generate more than one protein product from a single gene and to regulate mRNA stability and translational activity. An important example of the latter function involves an interplay between AS and NMD (nonsense-me...

Full description

Saved in:
Bibliographic Details
Main Authors: Hamid, Fursham M., Makeyev, Eugene V.
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2015
Subjects:
AS-NMD
Development
Post-transcriptional regulation of gene expression
Physiological response
RNA metabolism
Online Access:https://hdl.handle.net/10356/80870
http://hdl.handle.net/10220/38868
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Nanyang Technological University
Language: English
Description
Summary:Higher eukaryotes rely on AS (alternative splicing) of pre-mRNAs (mRNA precursors) to generate more than one protein product from a single gene and to regulate mRNA stability and translational activity. An important example of the latter function involves an interplay between AS and NMD (nonsense-mediated decay), a cytoplasmic quality control mechanism eliminating mRNAs containing PTCs (premature translation termination codons). Although originally identified as an error surveillance process, AS-NMD additionally provides an efficient strategy for deterministic regulation of gene expression outputs. In this review, we discuss recently published examples of AS–NMD and delineate functional contexts where recurrent use of this mechanism orchestrates expression of important genes.

Similar Items