MicroRNAs and their potential therapeutic applications in neural tissue engineering

• Main Authors: Nguyen, Lan Huong, Diao, Hua Jia, Chew, Sing Yian
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2015
• Subjects: RNA interference; Oligodendrocytes; Astrocytes; Neurons; Gene silencing; Nerve regeneration; Neural transdifferentiation; Neural differentiation
• Online Access: https://hdl.handle.net/10356/80905; http://hdl.handle.net/10220/38894
• Institution: Nanyang Technological University

The inherent poor regeneration capacity of nerve tissues, especially in the central nervous system, poses a grand challenge for neural tissue engineering. After injuries, the local microenvironment often contains potent inhibitory molecules and glial scars, which do not actively support axonal regro...