Neurofilament light as a blood biomarker for neurodegeneration in down syndrome

• Main Authors: Strydom, Andre, Heslegrave, Amanda, Startin, Carla M., Mok, Kin Y., Hardy, John, Groet, Jurgen, Nizetic, Dean, Zetterberg, Henrik
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2018
• Subjects: Alzheimer's Disease; Down Syndrome
• Online Access: https://hdl.handle.net/10356/81011; http://hdl.handle.net/10220/45065
• Institution: Nanyang Technological University

Background Down syndrome (DS) may be considered a genetic form of Alzheimer’s disease (AD) due to universal development of AD neuropathology, but diagnosis and treatment trials are hampered by a lack of reliable blood biomarkers. A potential biomarker is neurofilament light (NF-L), due to its ass...