Postnatal TrkB ablation in corticolimbic interneurons induces social dominance in male mice

• Main Authors: Chen, Albert I-Ming, Soong, Tuck Wah, Je, H. Shawn, Tan, Shawn, Xiao, Yixin, Yin, Henry H.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2019
• Subjects: Social Dominance; Prefrontal Cortex; Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/81153; http://hdl.handle.net/10220/50077
• Institution: Nanyang Technological University

Our ability to reason, feel, and socialize relies on the development of a tight balance between inhibition and excitation within cortical circuits. The growth factor BDNF and its receptor TrkB are important for inhibitory neuron development and have been implicated in neuropsychiatric disorders. How...