Alleviation of off-target effects from vector-encoded shRNAs via codelivered RNA decoys
Exogenous RNAi triggers such as shRNAs ideally exert their activities exclusively via the antisense strand that binds and silences designated target mRNAs. However, in principle, the sense strand also possesses silencing capacity that may contribute to adverse RNAi side effects including off-target...
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| Main Authors: | , , , , |
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| 格式: | Article |
| 語言: | English |
| 出版: |
2015
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| 主題: | |
| 在線閱讀: | https://hdl.handle.net/10356/81167 http://hdl.handle.net/10220/39147 |
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