The Effect of Dimethyl Sulfoxide on Supercoiled DNA Relaxation Catalyzed by Type I Topoisomerases

• Main Authors: Lv, Bei, Dai, Yunjia, Liu, Ju, Zhuge, Qiang, Li, Dawei
• 其他作者: School of Physical and Mathematical Sciences
• 格式: Article
• 語言: English
• 出版: 2015
• 主題: Chemistry and Biological Chemistry
• 在線閱讀: https://hdl.handle.net/10356/81342; http://hdl.handle.net/10220/39218
• 機構: Nanyang Technological University

The effects of dimethyl sulfoxide (DMSO) on supercoiled plasmid DNA relaxation catalyzed by two typical type I topoisomerases were investigated in our studies. It is shown that DMSO in a low concentration (less than 20%, v/v) can induce a dose-related enhancement of the relaxation efficiency of Esch...