Functional Evolution in Orthologous Cell-encoded RNA-dependent RNA Polymerases

• Main Authors: Qian, Xinlei, Hamid, Fursham M., El Sahili, Abbas, Darwis, Dina Amallia, Wong, Yee Hwa, Bhushan, Shashi, Makeyev, Eugene V., Lescar, Julien
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2016
• Subjects: RNA-dependent RNA polymerase; small RNAs
• Online Access: https://hdl.handle.net/10356/81833; http://hdl.handle.net/10220/40997
• Institution: Nanyang Technological University

Many eukaryotic organisms encode more than one RNA-dependent RNA polymerase (RdRP) that likely emerged as a result of gene duplication. Such RdRP paralogs often participate in distinct RNA silencing pathways and show characteristic repertoires of enzymatic activities in vitro. However, to what exten...