Palladacycle Promoted Base Controlled Regio- and Enantioselective Hydrophosphination of 2-Pyridylacrylate/amide and the Cytotoxicity of their Gold Complexes

Palladacycle Promoted Base Controlled Regio- and Enantioselective Hydrophosphination of 2-Pyridylacrylate/amide and the Cytotoxicity of their Gold Complexes

The regioselective asymmetric hydrophosphination of pyridine-functionalized alkenes can be achieved in the presence of stoichiometric amounts of the chiral palladium complex (R)-1. The presence or absence of base affords the respective β- and α-adducts with excellent regiocontrol. Chiral gold-phosph...

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Bibliographic Details
Main Authors: Jia, Yu-Xiang, Chew, Renta Jonathan, Li, Bin-Bin, Zhu, Pengcheng, Li, Yongxin, Pullarkat, Sumod Appukuttan, Tan, Nguan Soon, Leung, Pak-Hing
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2016
Subjects:
Palladium compounds
antineoplastic agent
Online Access:https://hdl.handle.net/10356/81881
http://hdl.handle.net/10220/39745
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Institution: Nanyang Technological University
Language: English

Internet

https://hdl.handle.net/10356/81881
http://hdl.handle.net/10220/39745

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