Palladacycle Promoted Base Controlled Regio- and Enantioselective Hydrophosphination of 2-Pyridylacrylate/amide and the Cytotoxicity of their Gold Complexes
The regioselective asymmetric hydrophosphination of pyridine-functionalized alkenes can be achieved in the presence of stoichiometric amounts of the chiral palladium complex (R)-1. The presence or absence of base affords the respective β- and α-adducts with excellent regiocontrol. Chiral gold-phosph...
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2016
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sg-ntu-dr.10356-818812023-02-28T16:59:02Z Palladacycle Promoted Base Controlled Regio- and Enantioselective Hydrophosphination of 2-Pyridylacrylate/amide and the Cytotoxicity of their Gold Complexes Jia, Yu-Xiang Chew, Renta Jonathan Li, Bin-Bin Zhu, Pengcheng Li, Yongxin Pullarkat, Sumod Appukuttan Tan, Nguan Soon Leung, Pak-Hing School of Biological Sciences School of Physical and Mathematical Sciences Palladium compounds antineoplastic agent The regioselective asymmetric hydrophosphination of pyridine-functionalized alkenes can be achieved in the presence of stoichiometric amounts of the chiral palladium complex (R)-1. The presence or absence of base affords the respective β- and α-adducts with excellent regiocontrol. Chiral gold-phosphine complexes incorporating the adducts exhibited good in vitro anticancer activity against the breast cancer cell line MDA-MB-231. Selectivity between the cancer cell line and normal cells was also observed. Accepted version 2016-01-22T01:36:43Z 2019-12-06T14:42:15Z 2016-01-22T01:36:43Z 2019-12-06T14:42:15Z 2015 Journal Article Jia, Y.-X., Chew, R. J., Li, B.-B., Zhu, P., Li, Y., Pullarkat, S. A., et al. (2015). Palladacycle promoted base controlled regio- and enantioselective hydrophosphination of 2-pyridylacrylate/amide and the cytotoxicity of their gold complexes. Dalton Transactions, 44(40), 17557-17564. 1477-9226 https://hdl.handle.net/10356/81881 http://hdl.handle.net/10220/39745 10.1039/C5DT02694F en Dalton Transactions © 2015 The Royal Society of Chemistry. This is the author created version of a work that has been peer reviewed and accepted for publication by Dalton Transactions, The Royal Society of Chemistry. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1039/C5DT02694F]. 7 p. application/pdf |
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Palladium compounds antineoplastic agent |
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Palladium compounds antineoplastic agent Jia, Yu-Xiang Chew, Renta Jonathan Li, Bin-Bin Zhu, Pengcheng Li, Yongxin Pullarkat, Sumod Appukuttan Tan, Nguan Soon Leung, Pak-Hing Palladacycle Promoted Base Controlled Regio- and Enantioselective Hydrophosphination of 2-Pyridylacrylate/amide and the Cytotoxicity of their Gold Complexes |
| description |
The regioselective asymmetric hydrophosphination of pyridine-functionalized alkenes can be achieved in the presence of stoichiometric amounts of the chiral palladium complex (R)-1. The presence or absence of base affords the respective β- and α-adducts with excellent regiocontrol. Chiral gold-phosphine complexes incorporating the adducts exhibited good in vitro anticancer activity against the breast cancer cell line MDA-MB-231. Selectivity between the cancer cell line and normal cells was also observed. |
| author2 |
School of Biological Sciences |
| author_facet |
School of Biological Sciences Jia, Yu-Xiang Chew, Renta Jonathan Li, Bin-Bin Zhu, Pengcheng Li, Yongxin Pullarkat, Sumod Appukuttan Tan, Nguan Soon Leung, Pak-Hing |
| format |
Article |
| author |
Jia, Yu-Xiang Chew, Renta Jonathan Li, Bin-Bin Zhu, Pengcheng Li, Yongxin Pullarkat, Sumod Appukuttan Tan, Nguan Soon Leung, Pak-Hing |
| author_sort |
Jia, Yu-Xiang |
| title |
Palladacycle Promoted Base Controlled Regio- and Enantioselective Hydrophosphination of 2-Pyridylacrylate/amide and the Cytotoxicity of their Gold Complexes |
| title_short |
Palladacycle Promoted Base Controlled Regio- and Enantioselective Hydrophosphination of 2-Pyridylacrylate/amide and the Cytotoxicity of their Gold Complexes |
| title_full |
Palladacycle Promoted Base Controlled Regio- and Enantioselective Hydrophosphination of 2-Pyridylacrylate/amide and the Cytotoxicity of their Gold Complexes |
| title_fullStr |
Palladacycle Promoted Base Controlled Regio- and Enantioselective Hydrophosphination of 2-Pyridylacrylate/amide and the Cytotoxicity of their Gold Complexes |
| title_full_unstemmed |
Palladacycle Promoted Base Controlled Regio- and Enantioselective Hydrophosphination of 2-Pyridylacrylate/amide and the Cytotoxicity of their Gold Complexes |
| title_sort |
palladacycle promoted base controlled regio- and enantioselective hydrophosphination of 2-pyridylacrylate/amide and the cytotoxicity of their gold complexes |
| publishDate |
2016 |
| url |
https://hdl.handle.net/10356/81881 http://hdl.handle.net/10220/39745 |
| _version_ |
1759857460715192320 |