Dynamic Transcription of Distinct Classes of Endogenous Retroviral Elements Marks Specific Populations of Early Human Embryonic Cells

• Main Authors: Göke, Jonathan, Lu, Xinyi, Chan, Yun-Shen, Ng, Huck-Hui, Ly, Lam-Ha, Sachs, Friedrich, Szczerbinska, Iwona
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2016
• Subjects: transposon; embryo
• Online Access: https://hdl.handle.net/10356/82005; http://hdl.handle.net/10220/41057
• Institution: Nanyang Technological University

About half of the human genome consists of highly repetitive elements, most of which are considered dispensable for human life. Here, we report that repetitive elements originating from endogenous retroviruses (ERVs) are systematically transcribed during human early embryogenesis in a stage-specific...