Communication: Capturing protein multiscale thermal fluctuations

• Main Authors: Opron, Kristopher, Xia, Kelin, Wei, Guo-Wei
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2016
• Subjects: Crystal structure; Proteins
• Online Access: https://hdl.handle.net/10356/82118; http://hdl.handle.net/10220/41114
• Institution: Nanyang Technological University

Existing elastic network models are typically parametrized at a given cutoff distance and often fail to properly predict the thermal fluctuation of many macromolecules that involve multiple characteristic length scales. We introduce a multiscale flexibility-rigidity index (mFRI) method to resolve th...