Carbene-catalyzed desymmetrization of 1,3-diols: access to optically enriched tertiary alkyl chlorides

• Main Authors: Li, Bao-Sheng, Wang, Yuhuang, Proctor, Rupert S. J., Jin, Zhichao, Chi, Yonggui Robin
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2017
• Subjects: Tertiary alkyl chlorides; Carbene-catalyzed reactions
• Online Access: https://hdl.handle.net/10356/82223; http://hdl.handle.net/10220/43497
• Institution: Nanyang Technological University

The introduction of a chlorine atom to a carbon center in an enantioselective manner via conventional C–Cl bond formation is difficult. Here we report a new approach to this class of tertiary alkyl chlorides with high optical purities. Instead of forming a new C–Cl bond, our approach involves carben...