Carbene-catalyzed desymmetrization of 1,3-diols: access to optically enriched tertiary alkyl chlorides

• المؤلفون الرئيسيون: Li, Bao-Sheng, Wang, Yuhuang, Proctor, Rupert S. J., Jin, Zhichao, Chi, Yonggui Robin
• مؤلفون آخرون: School of Physical and Mathematical Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2017
• الموضوعات: Tertiary alkyl chlorides; Carbene-catalyzed reactions
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/82223; http://hdl.handle.net/10220/43497
• المؤسسة: Nanyang Technological University

The introduction of a chlorine atom to a carbon center in an enantioselective manner via conventional C–Cl bond formation is difficult. Here we report a new approach to this class of tertiary alkyl chlorides with high optical purities. Instead of forming a new C–Cl bond, our approach involves carben...