Controlling the burst release of amorphous drug–polysaccharide nanoparticle complex via crosslinking of the polysaccharide chains

• المؤلفون الرئيسيون: Nguyen, Minh-Hiep, Tran, The-Thien, Hadinoto, Kunn
• مؤلفون آخرون: School of Chemical and Biomedical Engineering
• التنسيق: مقال
• اللغة: English
• منشور في: 2016
• الموضوعات: Amorphization; Drug–polysaccharide complex
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/82276; http://hdl.handle.net/10220/41174

High-payload amorphous drug–polysaccharide nanoparticle complex (or nanoplex in short) represents a new class of supersaturating drug delivery systems intended for bioavailability enhancement of poorly-soluble drugs. Not unlike other nanoscale amorphous formulations, the nanoplex exhibits fast disso...