Polysubstituted pyrrole derivatives via 1,2-alkenyl migration of novel γ-amino-α,β-unsaturated aldehydes and α-diazocarbonyls
Tri-substituted pyrrole derivatives were successfully synthesized from aminoaldehyde and α-diazocarbonyl, using a TiCl4 catalyst. The reactions proceeded via 1,2-migration and condensation, leading to the corresponding pyrroles in moderate to excellent yields. Reaction susceptibility was subsequentl...
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| Main Authors: | , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
2016
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/82357 http://hdl.handle.net/10220/39985 |
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| Institution: | Nanyang Technological University |
| Language: | English |
| Summary: | Tri-substituted pyrrole derivatives were successfully synthesized from aminoaldehyde and α-diazocarbonyl, using a TiCl4 catalyst. The reactions proceeded via 1,2-migration and condensation, leading to the corresponding pyrroles in moderate to excellent yields. Reaction susceptibility was subsequently demonstrated by the variation in substrates. |
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