Discovery of Influenza A Virus Sequence Pairs and Their Combinations for Simultaneous Heterosubtypic Targeting that Hedge against Antiviral Resistance

• Main Authors: Wee, Keng Boon, Lee, Raphael Tze Chuen, Lin, Jing, Pramono, Zacharias Aloysius Dwi, Maurer-Stroh, Sebastian
• Other Authors: Kosakovsky Pond, Sergei L.
• Format: Article
• Language: English
• Published: 2016
• Subjects: Biological Sciences
• Online Access: https://hdl.handle.net/10356/82452; http://hdl.handle.net/10220/40014
• Institution: Nanyang Technological University

The multiple circulating human influenza A virus subtypes coupled with the perpetual genomic mutations and segment reassortment events challenge the development of effective therapeutics. The capacity to drug most RNAs motivates the investigation on viral RNA targets. 123,060 segment sequences from...