Tropomyosin movement is described by a quantitative high-resolution model of X-ray diffraction of contracting muscle

• Main Authors: Koubassova, Natalia A., Bershitsky, Sergey Y., Ferenczi, Michael Alan, Narayanan, Theyencheri, Tsaturyan, Andrey K.
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2017
• Subjects: Actin; Tropomyosin
• Online Access: https://hdl.handle.net/10356/82598; http://hdl.handle.net/10220/42316
• Institution: Nanyang Technological University

Contraction of skeletal and cardiac muscle is controlled by Ca2+ ions via regulatory proteins, troponin (Tn) and tropomyosin (Tpm) associated with the thin actin filaments in sarcomeres. In the absence of Ca2+, Tn-C binds actin and shifts the Tpm strand to a position where it blocks myosin binding t...