Precision oncology : oncogenic stat3 signalling in brain tumours

• Main Author: Tan, Melanie Si Yan
• Other Authors: Tan Nguan Soon, Andrew
• Format: Theses and Dissertations
• Language: English
• Published: 2019
• Subjects: Science::Biological sciences::Human anatomy and physiology::Neurobiology; Science::Biological sciences::Molecular biology
• Online Access: https://hdl.handle.net/10356/82741; http://hdl.handle.net/10220/49094
• Institution: Nanyang Technological University

Brain tumour patients diagnosed with grade IV glioblastoma often show dismal prognosis despite the standard of care chemo- and radiation therapies. The Cancer Genome Atlas effort demonstrated that transcriptomic profiles distinguish three glioma-intrinsic subtypes, each with unique genetic aberratio...