Three-dimensional aligned nanofibers-hydrogel scaffold for controlled non-viral drug/gene delivery to direct axon regeneration in spinal cord injury treatment

• Main Authors: Nguyen, Lan Huong, Gao, Mingyong, Lin, Junquan, Wu, Wutian, Wang, Jun, Chew, Sing Yian
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2017
• Subjects: RNAi therapy; Protein delivery
• Online Access: https://hdl.handle.net/10356/83018; http://hdl.handle.net/10220/42377
• Institution: Nanyang Technological University

Spinal cord injuries (SCI) often lead to persistent neurological dysfunction due to failure in axon regeneration. Unfortunately, currently established treatments, such as direct drug administration, do not effectively treat SCI due to rapid drug clearance from our bodies. Here, we introduce a three-...