The C-terminal 18 Amino Acid Region of Dengue Virus NS5 Regulates its Subcellular Localization and Contains a Conserved Arginine Residue Essential for Infectious Virus Production

• Main Authors: Chan, Kitti W. K., Tay, Moon Y. F., Smith, Kate, Ng, Ivan H. W., Zhao, Yongqian, Ooi, Eng Eong, Lescar, Julien, Luo, Dahai, Jans, David A., Forwood, Jade K., Vasudevan, Subhash G.
• Other Authors: Rey, Félix A.
• Format: Article
• Language: English
• Published: 2017
• Subjects: C-terminal 18; Dengue Virus NS5
• Online Access: https://hdl.handle.net/10356/83021; http://hdl.handle.net/10220/42375
• Institution: Nanyang Technological University

Dengue virus NS5 is the most highly conserved amongst the viral non-structural proteins and is responsible for capping, methylation and replication of the flavivirus RNA genome. Interactions of NS5 with host proteins also modulate host immune responses. Although replication occurs in the cytoplasm,...