Developmental analysis of bone marrow neutrophils reveals populations specialized in expansion, trafficking, and effector functions

• Main Authors: Kwok, Immanuel Weng Han, Leong, Penny Hweixian, Evrard, Maximilien, Chong, Shu Zhen, Teng, Karen W.W., Becht, Etienne, Chen, Jinmiao, Sieow, Je Lin, Ching, Goh Chi, Devi, Sapna, Adrover, José Maria, Li, Jackson L.Y., Liong, Ka Hang, Tan, Leonard, Poon, Zhiyong, Foo, Shihui, Chua, Jia Wang, Su, I-Hsin, Balabanian, Karl, Bachelerie, Françoise, Biswas, Subhra K., Larbi, Anis, Hwang, William Y.K., Madan, Vikas, Koeffler, H. Phillip, Wong, Siew Cheng, Newell, Evan W., Hidalgo, Andrés, Ginhoux, Florent, Ng, Lai Guan
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2019
• Subjects: Granulopoiesis; Trafficking; Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/83127; http://hdl.handle.net/10220/50413
• Institution: Nanyang Technological University

Neutrophils are specialized innate cells that require constant replenishment from proliferative bone marrow (BM) precursors as a result of their short half-life. Although it is established that neutrophils are derived from the granulocyte-macrophage progenitor (GMP), the differentiation pathways fro...