Increased Serum Hyaluronic Acid and Heparan Sulfate in Dengue Fever: Association with Plasma Leakage and Disease Severity

Increased Serum Hyaluronic Acid and Heparan Sulfate in Dengue Fever: Association with Plasma Leakage and Disease Severity

Plasma leakage is a major pathogenic mechanism of severe dengue, but the etiology remains unclear. The association between endothelial glycocalyx integrity and vascular permeability in older adults with dengue has not been evaluated. A prospective cohort study of adults with undifferentiated fever s...

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Bibliographic Details
Main Authors: Tang, Tommy Hing-Cheung, Alonso, Sylvie, Ng, Lisa Fong-Poh, Thein, Tun-Linn, Pang, Vincent Jun-Xiong, Leo, Yee-Sin, Lye, David Chien-Boon, Yeo, Tsin-Wen
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Article
Language:English
Published: 2017
Subjects:
Serum hyaluronic acid (HA)
Plasma Leakage
Online Access:https://hdl.handle.net/10356/83192
http://hdl.handle.net/10220/42446
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Institution: Nanyang Technological University
Language: English
Description
Summary:Plasma leakage is a major pathogenic mechanism of severe dengue, but the etiology remains unclear. The association between endothelial glycocalyx integrity and vascular permeability in older adults with dengue has not been evaluated. A prospective cohort study of adults with undifferentiated fever screened for dengue by RT-PCR or NS1 antigen testing was performed. Patients were assessed daily while symptomatic and at convalescence.

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