Increased Serum Hyaluronic Acid and Heparan Sulfate in Dengue Fever: Association with Plasma Leakage and Disease Severity

• Main Authors: Tang, Tommy Hing-Cheung, Alonso, Sylvie, Ng, Lisa Fong-Poh, Thein, Tun-Linn, Pang, Vincent Jun-Xiong, Leo, Yee-Sin, Lye, David Chien-Boon, Yeo, Tsin-Wen
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2017
• Subjects: Serum hyaluronic acid (HA); Plasma Leakage
• Online Access: https://hdl.handle.net/10356/83192; http://hdl.handle.net/10220/42446
• Institution: Nanyang Technological University

Plasma leakage is a major pathogenic mechanism of severe dengue, but the etiology remains unclear. The association between endothelial glycocalyx integrity and vascular permeability in older adults with dengue has not been evaluated. A prospective cohort study of adults with undifferentiated fever s...