Increased Serum Hyaluronic Acid and Heparan Sulfate in Dengue Fever: Association with Plasma Leakage and Disease Severity

Plasma leakage is a major pathogenic mechanism of severe dengue, but the etiology remains unclear. The association between endothelial glycocalyx integrity and vascular permeability in older adults with dengue has not been evaluated. A prospective cohort study of adults with undifferentiated fever s...

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Main Authors:	Tang, Tommy Hing-Cheung, Alonso, Sylvie, Ng, Lisa Fong-Poh, Thein, Tun-Linn, Pang, Vincent Jun-Xiong, Leo, Yee-Sin, Lye, David Chien-Boon, Yeo, Tsin-Wen
Other Authors:	Lee Kong Chian School of Medicine (LKCMedicine)
Format:	Article
Language:	English
Published:	2017
Subjects:	Serum hyaluronic acid (HA) Plasma Leakage
Online Access:	https://hdl.handle.net/10356/83192 http://hdl.handle.net/10220/42446
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Institution:	Nanyang Technological University
Language:	English

id	sg-ntu-dr.10356-83192
record_format	dspace
spelling	sg-ntu-dr.10356-831922020-11-01T05:32:07Z Increased Serum Hyaluronic Acid and Heparan Sulfate in Dengue Fever: Association with Plasma Leakage and Disease Severity Tang, Tommy Hing-Cheung Alonso, Sylvie Ng, Lisa Fong-Poh Thein, Tun-Linn Pang, Vincent Jun-Xiong Leo, Yee-Sin Lye, David Chien-Boon Yeo, Tsin-Wen Lee Kong Chian School of Medicine (LKCMedicine) Serum hyaluronic acid (HA) Plasma Leakage Plasma leakage is a major pathogenic mechanism of severe dengue, but the etiology remains unclear. The association between endothelial glycocalyx integrity and vascular permeability in older adults with dengue has not been evaluated. A prospective cohort study of adults with undifferentiated fever screened for dengue by RT-PCR or NS1 antigen testing was performed. Patients were assessed daily while symptomatic and at convalescence. NMRC (Natl Medical Research Council, S’pore) Published version 2017-05-17T07:53:08Z 2019-12-06T15:13:44Z 2017-05-17T07:53:08Z 2019-12-06T15:13:44Z 2017 Journal Article Tang, T. H. -C., Alonso, S., Ng, L. F. -P., Thein, T. -L., Pang, V. J. -X., Leo, Y. -S., et al. (2017). Increased Serum Hyaluronic Acid and Heparan Sulfate in Dengue Fever: Association with Plasma Leakage and Disease Severity. Scientific Reports, 7, 46191-. 2045-2322 https://hdl.handle.net/10356/83192 http://hdl.handle.net/10220/42446 10.1038/srep46191 en Scientific Reports This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ 9 p. application/pdf
institution	Nanyang Technological University
building	NTU Library
continent	Asia
country	Singapore Singapore
content_provider	NTU Library
collection	DR-NTU
language	English
topic	Serum hyaluronic acid (HA) Plasma Leakage
spellingShingle	Serum hyaluronic acid (HA) Plasma Leakage Tang, Tommy Hing-Cheung Alonso, Sylvie Ng, Lisa Fong-Poh Thein, Tun-Linn Pang, Vincent Jun-Xiong Leo, Yee-Sin Lye, David Chien-Boon Yeo, Tsin-Wen Increased Serum Hyaluronic Acid and Heparan Sulfate in Dengue Fever: Association with Plasma Leakage and Disease Severity
description	Plasma leakage is a major pathogenic mechanism of severe dengue, but the etiology remains unclear. The association between endothelial glycocalyx integrity and vascular permeability in older adults with dengue has not been evaluated. A prospective cohort study of adults with undifferentiated fever screened for dengue by RT-PCR or NS1 antigen testing was performed. Patients were assessed daily while symptomatic and at convalescence.
author2	Lee Kong Chian School of Medicine (LKCMedicine)
author_facet	Lee Kong Chian School of Medicine (LKCMedicine) Tang, Tommy Hing-Cheung Alonso, Sylvie Ng, Lisa Fong-Poh Thein, Tun-Linn Pang, Vincent Jun-Xiong Leo, Yee-Sin Lye, David Chien-Boon Yeo, Tsin-Wen
format	Article
author	Tang, Tommy Hing-Cheung Alonso, Sylvie Ng, Lisa Fong-Poh Thein, Tun-Linn Pang, Vincent Jun-Xiong Leo, Yee-Sin Lye, David Chien-Boon Yeo, Tsin-Wen
author_sort	Tang, Tommy Hing-Cheung
title	Increased Serum Hyaluronic Acid and Heparan Sulfate in Dengue Fever: Association with Plasma Leakage and Disease Severity
title_short	Increased Serum Hyaluronic Acid and Heparan Sulfate in Dengue Fever: Association with Plasma Leakage and Disease Severity
title_full	Increased Serum Hyaluronic Acid and Heparan Sulfate in Dengue Fever: Association with Plasma Leakage and Disease Severity
title_fullStr	Increased Serum Hyaluronic Acid and Heparan Sulfate in Dengue Fever: Association with Plasma Leakage and Disease Severity
title_full_unstemmed	Increased Serum Hyaluronic Acid and Heparan Sulfate in Dengue Fever: Association with Plasma Leakage and Disease Severity
title_sort	increased serum hyaluronic acid and heparan sulfate in dengue fever: association with plasma leakage and disease severity
publishDate	2017
url	https://hdl.handle.net/10356/83192 http://hdl.handle.net/10220/42446
_version_	1683494571897520128

Increased Serum Hyaluronic Acid and Heparan Sulfate in Dengue Fever: Association with Plasma Leakage and Disease Severity

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