Implementation of machine learning and other simulation protocols for the representation of G-Quadruplex stabilizer

• Main Author: Chiew, Kang Jing
• Other Authors: Chen Gang
• Format: Theses and Dissertations
• Language: English
• Published: 2019
• Subjects: Science::Chemistry
• Online Access: https://hdl.handle.net/10356/83241; http://hdl.handle.net/10220/50085
• Institution: Nanyang Technological University

Human chromosomal telomeres are capable of forming G-Quadruplex structures, which can inhibit the activity of telomerase, an enzyme commonly found in cancerous cells and largely responsible for their immortality. The inhibition may therefore lead to cell apoptosis in these cancer cells. As such, the...