Renal-clearable molecular semiconductor for second near-infrared fluorescence imaging of kidney dysfunction
Real-time imaging of kidney function is important to assess the nephrotoxicity of drugs and monitor the progression of renal diseases; however, it remains challenging because of the lack of optical agents with high renal clearance and high signal-tobackground ratio (SBR). Herein, a second near-infra...
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| Main Authors: | , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
2019
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/83301 http://hdl.handle.net/10220/50094 |
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| Institution: | Nanyang Technological University |
| Language: | English |
| Summary: | Real-time imaging of kidney function is important to assess the nephrotoxicity of drugs and monitor the progression of renal diseases; however, it remains challenging because of the lack of optical agents with high renal clearance and high signal-tobackground ratio (SBR). Herein, a second near-infrared (NIR-II)
fluorescent molecular semiconductor (CDIR2) is synthesized for realtime
imaging of kidney dysfunction in living mice. CDIR2 not only has
a high renal clearance efficiency (~90% injection dosage at 24 h postinjection),
but also solely undergoes glomerular filtration into urine without being reabsorbed and secreted in renal tubules. Such a unidirectional renal clearance pathway of CDIR2 permits real-time monitoring of kidney dysfunction in living mice upon nephrotoxic exposure. Thus, this study not only introduces a molecular renal probe but also provides useful molecular guidelines to increase the renal clearance efficiency of NIR-II fluorescent agents. |
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