Spinal cord organoids add an extra dimension to traditional motor neuron cultures
Since Lancaster et al. (2013) first described the formation of self-organizing cerebral organoids for modeling neurodevelopmental disorders, it became evident that three-dimensional (3D) neural organoid cultures are more superior systems for modeling neurodevelopment and neurodegeneration in human....
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| المؤلفون الرئيسيون: | , , , |
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| مؤلفون آخرون: | |
| التنسيق: | مقال |
| اللغة: | English |
| منشور في: |
2019
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| الموضوعات: | |
| الوصول للمادة أونلاين: | https://hdl.handle.net/10356/83527 http://hdl.handle.net/10220/49761 |
| الوسوم: |
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| المؤسسة: | Nanyang Technological University |
| اللغة: | English |
| الملخص: | Since Lancaster et al. (2013) first described the formation of self-organizing cerebral organoids for modeling neurodevelopmental disorders, it became evident that three-dimensional (3D) neural organoid cultures are more superior systems for modeling neurodevelopment and neurodegeneration in human. The use of a spinning bioreactor to grow organoids allows better nutrient absorption and enhances formation of neuroepithelial-like zones, making it a great tool to study neurodevelopment and neurodegeneration. Neural organoids are 3D cell culture systems formed by proliferating, differentiating, migrating and self-organizing pools of neural progenitors. They mimic brain structures in their cell type composition, cytoarchitecture, and to some extent maturity and functionality (Lancaster et al., 2013). |
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