Super-Enhancers and Broad H3K4me3 Domains Form Complex Gene Regulatory Circuits Involving Chromatin Interactions

• Main Authors: Cao, Fan, Fang, Yiwen, Tan, Hong Kee, Goh, Yufen, Choy, Jocelyn Yeen Hui, Koh, Bryan Thean Howe, Hao Tan, Jiong, Bertin, Nicolas, Ramadass, Aroul, Hunter, Ewan, Green, Jayne, Salter, Matthew, Akoulitchev, Alexandre, Wang, Wilson, Chng, Wee Joo, Tenen, Daniel G., Fullwood, Melissa Jane
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2017
• Subjects: Chronic myeloid leukaemia; Genome informatics
• Online Access: https://hdl.handle.net/10356/83768; http://hdl.handle.net/10220/42747
• Institution: Nanyang Technological University

Stretched histone regions, such as super-enhancers and broad H3K4me3 domains, are associated with maintenance of cell identity and cancer. We connected super-enhancers and broad H3K4me3 domains in the K562 chronic myelogenous leukemia cell line as well as the MCF-7 breast cancer cell line with chrom...