The gut microbiota influences blood-brain barrier permeability in mice

Pivotal to brain development and function is an intact blood-brain barrier (BBB), which acts as a gatekeeper to control the passage and exchange of molecules and nutrients between the circulatory system and the brain parenchyma. The BBB also ensures homeostasis of the central nervous system (CNS). W...

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Main Authors: Braniste, Viorica, Al-Asmakh, Maha, Kowal, Czeslawa, Anuar, Farhana, Abbaspour, Afrouz, Tóth, Miklós, Korecka, Agata, Bakocevic, Nadja, Ng, Lai Guan, Kundu, Parag, Gulyás, Balázs, Halldin, Christer, Hultenby, Kjell, Nilsson, Harriet, Hebert, Hans, Volpe, Bruce T., Diamond, Betty, Pettersson, Sven
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Article
Language:English
Published: 2016
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Online Access:https://hdl.handle.net/10356/83794
http://hdl.handle.net/10220/41486
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-837942022-02-16T16:30:14Z The gut microbiota influences blood-brain barrier permeability in mice Braniste, Viorica Al-Asmakh, Maha Kowal, Czeslawa Anuar, Farhana Abbaspour, Afrouz Tóth, Miklós Korecka, Agata Bakocevic, Nadja Ng, Lai Guan Kundu, Parag Gulyás, Balázs Halldin, Christer Hultenby, Kjell Nilsson, Harriet Hebert, Hans Volpe, Bruce T. Diamond, Betty Pettersson, Sven Lee Kong Chian School of Medicine (LKCMedicine) Singapore Centre for Environmental Life Sciences Engineering Blood brain barrier Microbiota Pivotal to brain development and function is an intact blood-brain barrier (BBB), which acts as a gatekeeper to control the passage and exchange of molecules and nutrients between the circulatory system and the brain parenchyma. The BBB also ensures homeostasis of the central nervous system (CNS). We report that germ-free mice, beginning with intrauterine life, displayed increased BBB permeability compared to pathogen-free mice with a normal gut flora. The increased BBB permeability was maintained in germ-free mice after birth and during adulthood and was associated with reduced expression of the tight junction proteins occludin and claudin-5, which are known to regulate barrier function in endothelial tissues. Exposure of germ-free adult mice to a pathogen-free gut microbiota decreased BBB permeability and up-regulated the expression of tight junction proteins. Our results suggest that gut microbiota–BBB communication is initiated during gestation and propagated throughout life. ASTAR (Agency for Sci., Tech. and Research, S’pore) 2016-09-23T07:04:43Z 2019-12-06T15:32:12Z 2016-09-23T07:04:43Z 2019-12-06T15:32:12Z 2014 Journal Article Braniste, V., Al-Asmakh, M., Kowal, C., Anuar, F., Abbaspour, A., Toth, M., et al. (2014). The gut microbiota influences blood-brain barrier permeability in mice. Science Translational Medicine, 6(263), 263ra158-. 1946-6234 https://hdl.handle.net/10356/83794 http://hdl.handle.net/10220/41486 10.1126/scitranslmed.3009759 25411471 en Science Translational Medicine © 2014 American Association for the Advancement of Science.
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Blood brain barrier
Microbiota
spellingShingle Blood brain barrier
Microbiota
Braniste, Viorica
Al-Asmakh, Maha
Kowal, Czeslawa
Anuar, Farhana
Abbaspour, Afrouz
Tóth, Miklós
Korecka, Agata
Bakocevic, Nadja
Ng, Lai Guan
Kundu, Parag
Gulyás, Balázs
Halldin, Christer
Hultenby, Kjell
Nilsson, Harriet
Hebert, Hans
Volpe, Bruce T.
Diamond, Betty
Pettersson, Sven
The gut microbiota influences blood-brain barrier permeability in mice
description Pivotal to brain development and function is an intact blood-brain barrier (BBB), which acts as a gatekeeper to control the passage and exchange of molecules and nutrients between the circulatory system and the brain parenchyma. The BBB also ensures homeostasis of the central nervous system (CNS). We report that germ-free mice, beginning with intrauterine life, displayed increased BBB permeability compared to pathogen-free mice with a normal gut flora. The increased BBB permeability was maintained in germ-free mice after birth and during adulthood and was associated with reduced expression of the tight junction proteins occludin and claudin-5, which are known to regulate barrier function in endothelial tissues. Exposure of germ-free adult mice to a pathogen-free gut microbiota decreased BBB permeability and up-regulated the expression of tight junction proteins. Our results suggest that gut microbiota–BBB communication is initiated during gestation and propagated throughout life.
author2 Lee Kong Chian School of Medicine (LKCMedicine)
author_facet Lee Kong Chian School of Medicine (LKCMedicine)
Braniste, Viorica
Al-Asmakh, Maha
Kowal, Czeslawa
Anuar, Farhana
Abbaspour, Afrouz
Tóth, Miklós
Korecka, Agata
Bakocevic, Nadja
Ng, Lai Guan
Kundu, Parag
Gulyás, Balázs
Halldin, Christer
Hultenby, Kjell
Nilsson, Harriet
Hebert, Hans
Volpe, Bruce T.
Diamond, Betty
Pettersson, Sven
format Article
author Braniste, Viorica
Al-Asmakh, Maha
Kowal, Czeslawa
Anuar, Farhana
Abbaspour, Afrouz
Tóth, Miklós
Korecka, Agata
Bakocevic, Nadja
Ng, Lai Guan
Kundu, Parag
Gulyás, Balázs
Halldin, Christer
Hultenby, Kjell
Nilsson, Harriet
Hebert, Hans
Volpe, Bruce T.
Diamond, Betty
Pettersson, Sven
author_sort Braniste, Viorica
title The gut microbiota influences blood-brain barrier permeability in mice
title_short The gut microbiota influences blood-brain barrier permeability in mice
title_full The gut microbiota influences blood-brain barrier permeability in mice
title_fullStr The gut microbiota influences blood-brain barrier permeability in mice
title_full_unstemmed The gut microbiota influences blood-brain barrier permeability in mice
title_sort gut microbiota influences blood-brain barrier permeability in mice
publishDate 2016
url https://hdl.handle.net/10356/83794
http://hdl.handle.net/10220/41486
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