Model systems for the study of Enterococcal colonization and infection

Enterococcus faecalis and Enterococcus faecium are common inhabitants of the human gastrointestinal tract, as well as frequent opportunistic pathogens. Enterococci cause a range of infections including, most frequently, infections of the urinary tract, catheterized urinary tract, bloodstream, wounds...

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Main Authors: Goh, H. M. Sharon, Yong, M. H. Adeline, Chong, Kelvin Kian Long, Kline, Kimberly A.
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2017
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Online Access:https://hdl.handle.net/10356/83886
http://hdl.handle.net/10220/42897
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-838862020-09-21T11:34:21Z Model systems for the study of Enterococcal colonization and infection Goh, H. M. Sharon Yong, M. H. Adeline Chong, Kelvin Kian Long Kline, Kimberly A. School of Biological Sciences Interdisciplinary Graduate School (IGS) Singapore Centre for Environmental Life Sciences Engineering Animal Models Enterococcus faecalis Enterococcus faecalis and Enterococcus faecium are common inhabitants of the human gastrointestinal tract, as well as frequent opportunistic pathogens. Enterococci cause a range of infections including, most frequently, infections of the urinary tract, catheterized urinary tract, bloodstream, wounds and surgical sites, and heart valves in endocarditis. Enterococcal infections are often biofilm-associated, polymicrobial in nature, and resistant to antibiotics of last resort. Understanding Enterococcal mechanisms of colonization and pathogenesis are important for identifying new ways to manage and intervene with these infections. We review vertebrate and invertebrate model systems applied to study the most common E. faecalis and E. faecium infections, with emphasis on recent findings examining Enterococcal-host interactions using these models. We discuss strengths and shortcomings of each model, propose future animal models not yet applied to study mono- and polymicrobial infections involving E. faecalis and E. faecium, and comment on the significance of anti-virulence strategies derived from a fundamental understanding of host-pathogen interactions in model systems. NRF (Natl Research Foundation, S’pore) MOE (Min. of Education, S’pore) Published version 2017-07-18T04:19:43Z 2019-12-06T15:33:54Z 2017-07-18T04:19:43Z 2019-12-06T15:33:54Z 2017 Journal Article Goh, H. M. S., Yong, M. H. A., Chong, K. K. L., & Kline, K. A. (2017). Model systems for the study of Enterococcal colonization and infection. Virulence, 1-38. 2150-5594 https://hdl.handle.net/10356/83886 http://hdl.handle.net/10220/42897 10.1080/21505594.2017.1279766 en Virulence © 2017 The Author(s). Published with license by Taylor & Francis© H. M. Sharon Goh, M. H. Adeline Yong, Kelvin Kian Long Chong, and Kimberly A. Kline. This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted. 38 p. application/pdf
institution Nanyang Technological University
building NTU Library
country Singapore
collection DR-NTU
language English
topic Animal Models
Enterococcus faecalis
spellingShingle Animal Models
Enterococcus faecalis
Goh, H. M. Sharon
Yong, M. H. Adeline
Chong, Kelvin Kian Long
Kline, Kimberly A.
Model systems for the study of Enterococcal colonization and infection
description Enterococcus faecalis and Enterococcus faecium are common inhabitants of the human gastrointestinal tract, as well as frequent opportunistic pathogens. Enterococci cause a range of infections including, most frequently, infections of the urinary tract, catheterized urinary tract, bloodstream, wounds and surgical sites, and heart valves in endocarditis. Enterococcal infections are often biofilm-associated, polymicrobial in nature, and resistant to antibiotics of last resort. Understanding Enterococcal mechanisms of colonization and pathogenesis are important for identifying new ways to manage and intervene with these infections. We review vertebrate and invertebrate model systems applied to study the most common E. faecalis and E. faecium infections, with emphasis on recent findings examining Enterococcal-host interactions using these models. We discuss strengths and shortcomings of each model, propose future animal models not yet applied to study mono- and polymicrobial infections involving E. faecalis and E. faecium, and comment on the significance of anti-virulence strategies derived from a fundamental understanding of host-pathogen interactions in model systems.
author2 School of Biological Sciences
author_facet School of Biological Sciences
Goh, H. M. Sharon
Yong, M. H. Adeline
Chong, Kelvin Kian Long
Kline, Kimberly A.
format Article
author Goh, H. M. Sharon
Yong, M. H. Adeline
Chong, Kelvin Kian Long
Kline, Kimberly A.
author_sort Goh, H. M. Sharon
title Model systems for the study of Enterococcal colonization and infection
title_short Model systems for the study of Enterococcal colonization and infection
title_full Model systems for the study of Enterococcal colonization and infection
title_fullStr Model systems for the study of Enterococcal colonization and infection
title_full_unstemmed Model systems for the study of Enterococcal colonization and infection
title_sort model systems for the study of enterococcal colonization and infection
publishDate 2017
url https://hdl.handle.net/10356/83886
http://hdl.handle.net/10220/42897
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