Exploring cancer stem cell niche directed tumor growth

The finding that only a sub-fraction of tumor cells, so called Cancer Stem Cells (CSC), is endowed with the capacity to initiate new tumors has important consequences for fundamental as well as clinical cancer research. Previously we established by computational modeling techniques that CSC driven t...

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Main Authors: Sottoriva, Andrea., Sloot, Peter M. A., Medema, Jan Paul., Vermeulen, Louis.
Other Authors: School of Computer Engineering
Format: Article
Language:English
Published: 2013
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Online Access:https://hdl.handle.net/10356/84319
http://hdl.handle.net/10220/10174
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-843192020-05-28T07:17:41Z Exploring cancer stem cell niche directed tumor growth Sottoriva, Andrea. Sloot, Peter M. A. Medema, Jan Paul. Vermeulen, Louis. School of Computer Engineering DRNTU::Engineering::Computer science and engineering The finding that only a sub-fraction of tumor cells, so called Cancer Stem Cells (CSC), is endowed with the capacity to initiate new tumors has important consequences for fundamental as well as clinical cancer research. Previously we established by computational modeling techniques that CSC driven tumor growth instigates infiltrative behavior, and perhaps most interesting, stimulates tumor cell heterogeneity. An important question that remains is to what extend CSC functions are intrinsically regulated or whether this capacity is orchestrated by the microenvironment, i.e. a putative CSC niche. Here we investigate how extrinsic regulation of CSC properties affects the characteristics of malignancies. We find that highly invasive growth in tumors dependent on a small subset of cells is not restricted to CSC-driven tumors, but is also observed in tumors where the CSC capacity of tumor cells is completely defined by the microenvironment. Importantly, also the high level of heterogeneity that was observed for CSC-driven tumors is preserved and partially even increased in malignancies with a microenvironmentally orchestrated CSC population. This indicates that invasive growth and high heterogeneity are fundamental properties of tumors fueled by a small population of tumor cells. 2013-06-11T04:30:45Z 2019-12-06T15:42:42Z 2013-06-11T04:30:45Z 2019-12-06T15:42:42Z 2010 2010 Journal Article Sottoriva, A., Sloot, P. M. A., Medema, J. P., & Vermeulen, L. (2010). Exploring cancer stem cell niche directed tumor growth. Cell Cycle, 9(8), 1472-1479. https://hdl.handle.net/10356/84319 http://hdl.handle.net/10220/10174 10.4161/cc.9.8.11198 en Cell cycle © 2010 Landes Bioscience.
institution Nanyang Technological University
building NTU Library
country Singapore
collection DR-NTU
language English
topic DRNTU::Engineering::Computer science and engineering
spellingShingle DRNTU::Engineering::Computer science and engineering
Sottoriva, Andrea.
Sloot, Peter M. A.
Medema, Jan Paul.
Vermeulen, Louis.
Exploring cancer stem cell niche directed tumor growth
description The finding that only a sub-fraction of tumor cells, so called Cancer Stem Cells (CSC), is endowed with the capacity to initiate new tumors has important consequences for fundamental as well as clinical cancer research. Previously we established by computational modeling techniques that CSC driven tumor growth instigates infiltrative behavior, and perhaps most interesting, stimulates tumor cell heterogeneity. An important question that remains is to what extend CSC functions are intrinsically regulated or whether this capacity is orchestrated by the microenvironment, i.e. a putative CSC niche. Here we investigate how extrinsic regulation of CSC properties affects the characteristics of malignancies. We find that highly invasive growth in tumors dependent on a small subset of cells is not restricted to CSC-driven tumors, but is also observed in tumors where the CSC capacity of tumor cells is completely defined by the microenvironment. Importantly, also the high level of heterogeneity that was observed for CSC-driven tumors is preserved and partially even increased in malignancies with a microenvironmentally orchestrated CSC population. This indicates that invasive growth and high heterogeneity are fundamental properties of tumors fueled by a small population of tumor cells.
author2 School of Computer Engineering
author_facet School of Computer Engineering
Sottoriva, Andrea.
Sloot, Peter M. A.
Medema, Jan Paul.
Vermeulen, Louis.
format Article
author Sottoriva, Andrea.
Sloot, Peter M. A.
Medema, Jan Paul.
Vermeulen, Louis.
author_sort Sottoriva, Andrea.
title Exploring cancer stem cell niche directed tumor growth
title_short Exploring cancer stem cell niche directed tumor growth
title_full Exploring cancer stem cell niche directed tumor growth
title_fullStr Exploring cancer stem cell niche directed tumor growth
title_full_unstemmed Exploring cancer stem cell niche directed tumor growth
title_sort exploring cancer stem cell niche directed tumor growth
publishDate 2013
url https://hdl.handle.net/10356/84319
http://hdl.handle.net/10220/10174
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