Recent advances in chitosan-based carriers for gene delivery

Approximately 4000 diseases are associated with malfunctioning genes in a particular cell type. Gene-based therapy provides a platform to modify the disease-causing genes expression at the cellular level to treat pathological conditions. However, gene delivery is challenging as these therapeutic gen...

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Main Authors: Cao, Ye, Tan, Yang Fei, Wong, Yee Shan, Liew, Melvin Wen Jie, Venkatraman, Subbu
Other Authors: School of Materials Science and Engineering
Format: Article
Language:English
Published: 2019
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Online Access:https://hdl.handle.net/10356/84441
http://hdl.handle.net/10220/49788
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-844412023-07-14T15:51:32Z Recent advances in chitosan-based carriers for gene delivery Cao, Ye Tan, Yang Fei Wong, Yee Shan Liew, Melvin Wen Jie Venkatraman, Subbu School of Materials Science and Engineering Engineering::Materials Chitosan siRNA Approximately 4000 diseases are associated with malfunctioning genes in a particular cell type. Gene-based therapy provides a platform to modify the disease-causing genes expression at the cellular level to treat pathological conditions. However, gene delivery is challenging as these therapeutic genes need to overcome several physiological and intracellular barriers in order, to reach the target cells. Over the years, efforts have been dedicated to develop efficient gene delivery vectors to overcome these systemic barriers. Chitosan, a versatile polysaccharide, is an attractive non-viral vector material for gene delivery mainly due to its cationic nature, biodegradability and biocompatibility. The present review discusses the design factors that are critical for efficient gene delivery/transfection and highlights the recent progress of gene therapy using chitosan-based carriers. Published version 2019-08-27T05:09:30Z 2019-12-06T15:45:17Z 2019-08-27T05:09:30Z 2019-12-06T15:45:17Z 2019 Journal Article Cao, Y., Tan, Y. F., Wong, Y. S., Liew, M. W. J., & Venkatraman, S. (2019). Recent Advances in Chitosan-Based Carriers for Gene Delivery. Marine Drugs, 17(6), 381-. doi:10.3390/md17060381 1660-3397 https://hdl.handle.net/10356/84441 http://hdl.handle.net/10220/49788 10.3390/md17060381 en Marine Drugs © 2019 by the Authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). 21 p. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Engineering::Materials
Chitosan
siRNA
spellingShingle Engineering::Materials
Chitosan
siRNA
Cao, Ye
Tan, Yang Fei
Wong, Yee Shan
Liew, Melvin Wen Jie
Venkatraman, Subbu
Recent advances in chitosan-based carriers for gene delivery
description Approximately 4000 diseases are associated with malfunctioning genes in a particular cell type. Gene-based therapy provides a platform to modify the disease-causing genes expression at the cellular level to treat pathological conditions. However, gene delivery is challenging as these therapeutic genes need to overcome several physiological and intracellular barriers in order, to reach the target cells. Over the years, efforts have been dedicated to develop efficient gene delivery vectors to overcome these systemic barriers. Chitosan, a versatile polysaccharide, is an attractive non-viral vector material for gene delivery mainly due to its cationic nature, biodegradability and biocompatibility. The present review discusses the design factors that are critical for efficient gene delivery/transfection and highlights the recent progress of gene therapy using chitosan-based carriers.
author2 School of Materials Science and Engineering
author_facet School of Materials Science and Engineering
Cao, Ye
Tan, Yang Fei
Wong, Yee Shan
Liew, Melvin Wen Jie
Venkatraman, Subbu
format Article
author Cao, Ye
Tan, Yang Fei
Wong, Yee Shan
Liew, Melvin Wen Jie
Venkatraman, Subbu
author_sort Cao, Ye
title Recent advances in chitosan-based carriers for gene delivery
title_short Recent advances in chitosan-based carriers for gene delivery
title_full Recent advances in chitosan-based carriers for gene delivery
title_fullStr Recent advances in chitosan-based carriers for gene delivery
title_full_unstemmed Recent advances in chitosan-based carriers for gene delivery
title_sort recent advances in chitosan-based carriers for gene delivery
publishDate 2019
url https://hdl.handle.net/10356/84441
http://hdl.handle.net/10220/49788
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