Redox chemistry of Mycobacterium tuberculosis alkylhydroperoxide reductase E (AhpE): Structural and mechanistic insight into a mycoredoxin-1 independent reductive pathway of AhpE via mycothiol

• Main Authors: Kumar, Arvind, Balakrishna, Asha Manikkoth, Nartey, Wilson, Manimekalai, Malathy Sony Subramanian, Grüber, Gerhard
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2016
• Subjects: AhpE; Alkyl hydroperoxide reductase
• Online Access: https://hdl.handle.net/10356/84711; http://hdl.handle.net/10220/41922
• Institution: Nanyang Technological University

Mycobacterium tuberculosis (Mtb) has the ability to persist within the human host for a long time in a dormant stage and re-merges when the immune system is compromised. The pathogenic bacterium employs an elaborate antioxidant defence machinery composed of the mycothiol- and thioredoxin system in a...