Identifying novel strategies for treating human hair loss disorders : cyclosporine A suppresses the Wnt inhibitor, SFRP1, in the dermal papilla of human scalp hair follicles

• Main Authors: Hawkshaw, Nathan J., Hardman, Jonathan A., Haslam, Iain S., Shahmalak, Asim, Gilhar, Amos, Lim, Xinhong, Paus, Ralf
• Other Authors: Nusse, Roel
• Format: Article
• Language: English
• Published: 2018
• Subjects: Hair Follicles; SFRP1
• Online Access: https://hdl.handle.net/10356/84739; http://hdl.handle.net/10220/45125
• Institution: Nanyang Technological University

Hair growth disorders often carry a major psychological burden. Therefore, more effective human hair growth–modulatory agents urgently need to be developed. Here, we used the hypertrichosis-inducing immunosuppressant, Cyclosporine A (CsA), as a lead compound to identify new hair growth–promoting mol...