Identifying novel strategies for treating human hair loss disorders : cyclosporine A suppresses the Wnt inhibitor, SFRP1, in the dermal papilla of human scalp hair follicles

• Main Authors: Hawkshaw, Nathan J., Hardman, Jonathan A., Haslam, Iain S., Shahmalak, Asim, Gilhar, Amos, Lim, Xinhong, Paus, Ralf
• 其他作者: Nusse, Roel
• 格式: Article
• 語言: English
• 出版: 2018
• 主題: Hair Follicles; SFRP1
• 在線閱讀: https://hdl.handle.net/10356/84739; http://hdl.handle.net/10220/45125

Hair growth disorders often carry a major psychological burden. Therefore, more effective human hair growth–modulatory agents urgently need to be developed. Here, we used the hypertrichosis-inducing immunosuppressant, Cyclosporine A (CsA), as a lead compound to identify new hair growth–promoting mol...